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Envisioning the Future of Ocular Therapeutics
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Unmet Needs

Ophthalmic Diseases

The approximately $6 billion United States and European back-of-the-eye therapeutics represent key sight threatening diseases such as uveitis, diabetic macular edema, age related macular degeneration, and glaucoma. This is due to the large growing patient populations with eye diseases that have minimal satisfactory therapy.

Severe Uveitis

Uveitis is an inflammation of the uveal tract and may occur as a result of a diverse series of stimuli including infectious, traumatic and idiopathic causes. However, inflammation is common to all uveitis, regardless of etiology. The inflammation associated with uveitis may be acute, subacute or chronic. Uveitis is an under-diagnosed and under-recognized medical condition that causes vision impairment, ocular pain, and loss of vision. There is a major need for a safe, effective and approved non-invasive medication specifically for intermediate and posterior uveitis.

Chronic Macular Edema

Chronic macular edema entails the leakage of fluid from damaged blood vessels of the retina which when untreated, causes visual loss. It is the leading cause of blindness in those under the age of 60.

Age-Related Macular Degeneration

AMD is the most common cause of blindness and vision impairment in Americans aged 60 and older. Some population research predictions show that almost one-third of all people aged 75 years or more will develop at least some initial form of macular degeneration. Age-related macular degeneration is a condition that primarily affects the part of the retina responsible for sharp central vision. There are two forms of AMD—dry AMD and wet AMD. Because AMD often damages central vision, it is the most common cause of legal blindness and vision impairment in older Americans (AMD rarely affects those under the age of 60).

Diabetic Retinopathy

Diabetic retinopathy is believed to be a leading cause of blindness in the industrialized world in people between the ages of 25 and 74. Diabetic retinopathy is a common complication of diabetes. Retinal blood vessels can break down, leak, or become blocked, affecting and impairing vision over time. Nearly half of all people with diabetes will develop some degree of diabetic retinopathy during their lifetime, and risk increases with age and duration of diabetes.

Glaucoma

Glaucoma is a chronic disease that often requires life-long treatment to control. Glaucoma is a disease that causes gradual damage to the optic nerve that carries visual information from the eye to the brain. The loss of vision is not experienced until a significant amount of nerve damage has occurred. Thus, about half of all glaucoma cases are unknown to the prospective patient. Glaucoma is defined by three characteristics: elevated intraocular pressure, deterioration of visual fields, and cupping of the optic nerve. The elevated pressure in the eye is associated with changes in the appearance and function of the optic nerve. Typically, the disease is asymptomatic until the final states, when the visual field loss impinges on central vision.